Dr. David J. Langer


Director of the Center For Neurovascular Surgery
Roosevelt Hospital

Primary Specialty: Neurovascular/skull base and complex spinal surgery.

Dr. David Langer is a graduate of the University of Pennsylvania and its medical school. He remained at Penn for his neurosurgical training which he completed under the direction of Eugene Flamm until 1998. Upon the completion of his residency he joined Dr. Flamm as his first neurovascular fellow at Beth Israel Medical Center and the Institute for Neurology and Neurosurgery (INN). He also was a visiting attending at Academisch Zeikenhuis Utrecht in the Netherlands where he studied laser assisted cerebral bypass surgery and hopes to develop this technique in the USA. He remained on faculty following his fellowship and is currently an Assistant Professor of Neurosurgery at Albert Einstein College of Medicine and Attending Neurosurgeon at Beth Israel Medical Center.

Dr. Langer’s clinical interests include neurovascular surgery including arteriovenous malformations, aneurysms and carotid artery disease as well as complex spinal disorders and brain tumors. He additionally has developed a number of research interests in brain revascularization and RNA gene therapy. Dr. Langer is the author of many papers and chapters, and has lectured nationally and internationally on a number of topics in neurosurgery.

Affiliated with: St. Luke's Roosevelt Hospital Center, Beth Israel Medical Center, Long Island College Hospital, and the New York Eye and Ear Infirmary.

Scientific Publications

Please click here for Dr. Langer's latest publications.

Treatment of cerebral aneurysms with hydrogel coated platinum coils (HydroCoil): early single-center experience. AJNR AM J Neuroradiology 2006 Oct; 27(9):1834-40.

Langer DJ, Lefton DR, Ostergren L, Brockington C, Song J, Niimi Y, Bhargava P, Berenstein A.  Hemispheric revascularization in the setting of carotid occlusion and subclavian steal: a diagnostic and management role for quantitative magnetic resonance angiography?  Neurosurgery 2006 Mar;58(3):528-33; discussion 528-33

Langer DJ, Song J, Niimi Y, Chwajol M, Lefton DR, Brisman JL, Molofsky W, Kupersmith MJ, Berenstein A.  Transarterial embolization of vein of Galen malformations: the use of magnetic resonance imaging noninvasive optimal vessel analysis to quantify shunt reduction.  Report of two cases.  J Neurosurgery 2006 Jan;104(1Suppl):41-5

van Doormaal T.P.C., van der Zwan A., Verweij B.H., Langer D.J., and Tulleken C.A.F., Treatment of Giant and Large Internal Carotid Artery Aneurysms with a High Flow Replacement Bypass the Excimer Laser - Assisted Nonocclusive Anastomosis Technique, Operative Neurosurgery, Vol4: p328-335, Nov 2006.

Navraj S. Heran, MD, Joon K. Song, MD, Mark J. Kupersmith, MD, Yasunari Niimi, MD, Katsunari Namba, MD, David J. Langer, MD, and Alejandro Berenstein, MD, Large Ophthalmic Segment Aneurysms with Anterior Optic Pathway Compression: Assessment of Anatomic and Vision Outcomes, Accepted for publication J. neurosurgery 2006 Endosaccular Coil Therapy. Heran NS, Song JK, Kupersmith MJ, Niimi Y, Namba K, Langer DJ, Berenstein A. J Neurosurgery 2007 Jun;106(6):968-75

A. Szelenyi, D. Langer, K. Kothbauer, A. Bueno de Camargo, E. S. Flamm, V. Deletis, Motor evoked potentials monitoring during cerebral aneurysm surgery:  intraoperative changes and postoperative outcome, J Neurosurgery Vol 105:5, 2006

D. J. Langer, D. Lefton, L. Ostergren, C. Brockington,  J. Song, Y. Niimi , P. Bhargava , A. Berenstein, Diagnosis and Treatment of Occult Subclavian Steal in the Setting of Right Middle Cerebral Ischemia:  A Clinical Role for Quantitative MRA?, Neurosurgery 58, No 3: 528-533, March 2006

D. J. Langer, J. K. Song, Y. Niimi, M. Chwajol, D.R. Lefton, J.L. Brisman, M. J. Kupersmith, and A. Berenstein, Embolization of Vein of Galen Malformations: Quantification of Shunt Reduction with MR Non-invasive Optimal Vessel Analysis (NOVA), accepted for publication, J. Neurosurgery Pediatrics 104: 41-45,  January 2006

David J. Langer and Peter Vajkoczy, ELANA: Excimer Laser Assisted Nonocclusive Anastomosis for Extracranial to Intracranial and Intracranial to Intracranial Bypass:  A Review, Skull Base 15, No 3: 191-205, 2005.

A. Szelenyi, K. Kothbauer, A. Bueno de Camargo, D. Langer, E. Flamm, V. Deletis, Motor Evoked Potential Monitoring During Cerebral Aneurysm Surgery:  Technical Aspects and Comparison of Transcranial and Direct Cortical Stimulation, Operative Neurosurgery 57, No 4: 331- 338, 2005.

M.J. Kupersmith, H. Stiebel-Kalish, R. Huna-Baron, A. Setton, Y. Niimi, D. Langer, A. Berenstein, Cavernous Carotid Aneurysms Rarely Cause Subarachnoid Hemorrhage or Major Neurologic Morbidity, J. Stroke and Cerebrovascular Diseases, Vol 11, No 1: 9-14 ,2002

K. Kariko, J.M. Keller, V.A. Harris, D.J. Langer, F.S. Welsh, In Vivo Protein Expression from mRNA Delivered into Adult Rat Brain, J. Neurosci Methods, 105: 77-86, 2001

N.J. Volpe, M.C. Sharma, S.L. Galetta, D.J. Langer, G.T. Liu, R.W. Hurst, E.S. Flamm, Orbital Drainage from Cerebral Arteriovenous Malformations, Neurosurgery, 46(4): 820-824, 2000.

D.J. Langer, T.M. Lasner, R.W. Hurst, E.S. Flamm, E.L. Zager, J.T. King, Hypertension, Small Size, and Deep Venous Drainage Are Associated with Risk of Hemorrhagic Presentation of Cerebral Arteriovenous Malformations, Neurosurgery, 42(3): 481-489, 1998

K.Kariko, A. Kuo, E.S. Barnathan, D.J. Langer, Phosphate-enhanced transfection of cationic lipid-complexed mRNA and plasmid DNA, Biochimica et Biophysica Acta, 1369(2): 320-334, 1998

D.G. Neschis, S.D. Safford , P.N. Raghunath, D.J. Langer, M.L. David, A.K. Hanna, J.E. Tomaszewski, K. Kariko, E.S. Barnathan, M.A. Golden, Thermal Preconditioning Before Rat Arterial Balloon Injury: Limitation of Injury and Sustained Reduction of Intimal Thickening, Arterioscler Thromb Vasc Biol., 18:120-126, 1998

O'Connor W.M. , Davidson B.L., Kaplitt M.G., Abbey M.V., During M.J., Leone P., Langer D, O'Connor M.J., Freese A., Adenovirus Vector-Mediated Gene Transfer into Human Epileptogenic Brain Slices: Prospects for Gene Therapy in Epilepsy, Experimental Neurology, 148(1):167-178, 1997

A. Freese, M. G. Kaplitt, W.M. O'Connor, D.J. Langer, P. Leone, M.J. O'Connor, M.J. During, Direct Gene Transfer into Human Epileptogenic Hippocampal Tissue with an Adeno-associated Virus Vector: Implications for a gene therapy approach to epilepsy, Epilepsia, 38(7):759-766, 1997

Langer D.J., Kuo A., Kariko K., Ahuja M., Klugherz B., Ivanics K.M., Hoxie J.A., Williams W.V., Liang B.T., Cines D.B., Barnathan E.S., Regulation of the endothelial cell urokinase type plasminogen activator receptor:evidence for cAMP dependent and protein kinase C dependent pathways, Circulation Research, 72:330-340,1993

D.J. Langer, A. Kuo, K. Kariko, D.B. Cines, E.S. Barnathan, Regulation of the Urokinase Receptor on Human Endothelial Cells-Evidence for cAMP Dependent and Independent Pathways, Clinical Research 38:319A, 1990

D.B. Sattelle, D.J. Langer, C.A. Haniff, D.J. Ellar, Laser Light Scattering Determination of Size and Particle Composition of Delta Endotoxin Crystals from B. thuringiensis, Royal Society of Chemistry Dynamic Properties of Biomolecular Assemblies, 1989

Book Chapters
Schwartz LF and Langer DJ, Clinical Presentation of Cerebral Aneurysms and Subarachnoid Hemorrhage, In: LeRoux PD and Winn HR ed., Management of Cerebral Aneurysms, W.B. Saunders, Philadelphia, 2003

Langer D.J. and Flamm E.S., Surgical Treatment of Anterior Circulation Aneurysms, Neurobase 1999, Stein S. Ed

Langer D.J., Zager E., Flamm E.S., Parasurgical Management of Aneurysmal Subarachnoid Hemorrhage, In: Cruz, J. (ed.), Neurologic and Neurosurgical Emergencies, W.B. Saunders, Philadelphia, p. 205-241

Abstracts
D.J. Langer, R. Weil, P.M. Marcotte, Outcome Analysis for Repeat Cervical Surgery in the “Failed Neck” Patient, CNS 1997

K. Karikó*, E. S. Barnathan, V. M.-Y. Lee, Y. Rangel, D. J. Langer, F. A. Welsh, High Level of Protein Expression Achieved by mRNA Transfection In Cultured Neurons Rat Brain, Society for Neuroscience Abstract, 1997

D.J. Langer, K.J. Fisher, R.W. Malone, J.A. Hecker, E.S. Barnathan, F.A. Welsh, M.A. Dichter, K. Kariko, Adenoviral Penton Protein Improves Transfection Efficiency of mRNA and Plasmid DNA in Primary Neuroglial Cells, Society for Neuroscience Abstract, 1996

A. Freese, M.J. O'Connor, D.J. Langer, M. G. Kaplitt, W.M. O'Connor, M.J. During, Gene transfer into Human Hippocampal Tissue Using an Adeno-Associated Virus Vector: Prospects for Gene Therapy in Focal Epilepsy, CNS 1995 Abstract

J.G, Hecker, D.J. Langer, B.E. Marshall, E.S Barnathan, K. Kariko, Feasibility Studies of mRNA Transfection for Intermediate Duration, Perioperative Modulation of CNS Responses Accessible via Cerebrospinal Fluid, AUA 1995 Abstract

D.J. Langer, T.M. Lasner, R.W. Hurst, J.T. King, E.L. Zager, E.S. Flamm, Cerebral Arteriovenous Malformations: Risk of Hemorrhage Based on Angiographic and Clinical Criteria, AANS 1994 Abstract

A.L. Obaid, D.J. Langer, B.M. Salzberg, Charybdotoxin (CTX) Selectively Blocks Calcium Mediated Potassium Conductance that Contributes to the Action Potential Recorded Optically from Nerve Terminals of the Frog Neurohypophysis, Society for Neuroscience Abstract, 1985

Other Publications
Today My Dad Would Be Alive, D.J. Langer, Philadelphia Magazine, March, 1995 Awards

Talks

2006 St Louis University Cerebral Revascularization Meeting - Course Co-Director

2003 Neurosurgery Grand Rounds University of Illinois/Chicago "New Avenues In High Flow EC-IC Bypass"

2002 St Lous University Cerebral Revascularization Faculty "New Avenues In High Flow EC-IC Bypass"

2002/2003 Academy of Neurology “The Neurologist’s Role in a Multidisciplinary Approach to Cerebral Aneurysms, Pial and Dural AVMs”

2002 AANS/CNS Vascular Section Meeting, Management of Residual Anterior Communicating Artery Aneurysms in Patients with Subarachnoid Hemorrhage

2001 Beth Israel Medical Center CME series, “Neurosurgical Emergencies”
1999 Neurosurgery Grand Rounds Tufts University School of Medicine, “Controversies in the Management of Cerebral Arterial Aneurysms”

1999 International Society of Neurological Emergencies, “Clinical evaluation and management of acute hydrocephalus”
“Intensive care management of cerebral vasospasm”

1997 CNS Annual Meeting, “Outcome Analysis for Repeat Cervical Surgery in the “Failed Neck” Patient”

1996 Sedona Spring Brain Conference Plenary speaker, “Bypassing the Nucleus, mRNA as Gene Therapy”, 1996 Neuroemergency Meeting, “Intensive Care Management of Cerebral Arterial Vasospasm”, “Management of Acute Hydrocephalus, A Contemporary Approach”




 
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